个人简介

研究员，博士生导师，博雅青年学者。

教育经历

周岳于2010年毕业于北京生命科学研究所（NIBS）与兰州大学，获博士学位。2011年起，先后在美国梅奥医学中心、德国马克斯普朗克植物育种学研究所进行博士后/博士后研究员工作。2018年9月入职北京大学现代农学院，同时加入蛋白质与植物基因研究国家重点实验室、北京大学-清华大学生命科学联合中心（CLS）。

研究方向

周岳实验室致力于研究表观遗传调控在植物发育和植物对环境的响应中的作用，通过跨学科的研究方法，利用遗传学、基因组学、细胞生物学和生物化学等研究手段，重点研究植物染色体3D结构的分子机理以及生物学功能。主要研究结果以第一作者发表在Nature Genetics，Genome Biology, PNAS，Plant Cell，Plant Physiology等刊物上。回到北大后，以通讯作者在Nature Communications, Plant Cell发表文章，揭示了植物染色体一级以及3D结构的调控模式。

代表性成果

1.  Yin, X., Romero-Campero, F JM., Yang, M., Baile, F., Cao, Y., Shu, J., Luo, L., Wang, D., Sun, S., Yan, P., Gong, Z., Mo, X., Qin, G., Myriam, C#, Zhou, Y^#. (2023). Binding by the Polycomb complex component BMI1 and H2A monoubiquitination shape local and long-range interactions in the Arabidopsis genome. Plant Cell 35, 2484-2503. 10.1093/plcell/koad112.

2.  Yang, T.T., Wang, D.Y., Tian, G.M., Sun, L.H., Yang, M.Q., Yin, X.C., Xiao, J., Sheng, Y., Zhu, D.M., He, H., and Zhou, Y. (2022). Chromatin remodeling complexes regulate genome architecture in Arabidopsis. Plant Cell 34, 2638-2651. 10.1093/plcell/koac117.

3.  Wei, S.B., Li, X., Lu, Z.F., Zhang, H., Ye, X.Y., Zhou, Y.J., Li, J., Yan, Y.Y., Pei, H.C., Duan, F.Y., Wang D.Y., Song, C., Wang, P., Zhang, C., Shang, L.G., Zhou, Y., Yan, P., Zhao, M., Huang J.R., Bock, R., Qian, Q., Zhou W.B. (2022). A transcriptional regulator that boosts grain yields and shortens the growth duration of rice. Science 377, eabi8455. 10.1126/science.abi8455.

4.  Gao, Z., Zhou, Y., and He, Y. (2022). Molecular epigenetic mechanisms for the memory of temperature stresses in plants. J Genet Genomics 49, 991-1001. 10.1016/j.jgg.2022.07.004.

5.  Yin, X., Romero-Campero, F.J., de Los Reyes, P., Yan, P., Yang, J., Tian, G., Yang, X., Mo, X., Zhao, S., Calonje, M., and Zhou, Y. (2021). H2AK121ub in Arabidopsis associates with a less accessible chromatin state at transcriptional regulation hotspots. Nat Commun 12, 315. 10.1038/s41467-020-20614-1.

6.  Lan, J., Zhang, J., Yuan, R., Yu, H., An, F., Sun, L., Chen, H., Zhou, Y., Qian, W., He, H., and Qin, G. (2021). TCP Transcription Factors Suppress Cotyledon Trichomes by Impeding a Cell Differentiation-regulating Complex. Plant Physiol 186, 434-451. 10.1093/plphys/kiab053.

7.  Zhou, Y., Wang, Y., Krause, K., Yang, T., Dongus, J.A., Zhang, Y., and Turck, F. (2018). Telobox motifs recruit CLF/SWN-PRC2 for H3K27me3 deposition via TRB factors in Arabidopsis. Nat Genet 50, 638-644. 10.1038/s41588-018-0109-9.

8.  Xue, L., Klinnawee, L., Zhou, Y., Saridis, G., Vijayakumar, V., Brands, M., Dormann, P., Gigolashvili, T., Turck, F., and Bucher, M. (2018). AP2 transcription factor CBX1 with a specific function in symbiotic exchange of nutrients in mycorrhizal Lotus japonicus. Proc Natl Acad Sci U S A 115, E9239-E9246. 10.1073/pnas.1812275115.

9.  Cui, H., Qiu, J., Zhou, Y., Bhandari, D.D., Zhao, C., Bautor, J., and Parker, J.E. (2018). Antagonism of transcription factor MYC2 by EDS1/PAD4 complexes bolsters salicylic acid defense in Arabidopsis effector-triggered immunity. Mol Plant 11, 1053-1066. 10.1016/j.molp.2018.05.007.

10. Zhou, Y., Tergemina, E., Cui, H., Forderer, A., Hartwig, B., Velikkakam James, G., Schneeberger, K., and Turck, F. (2017). Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana. Proc Natl Acad Sci U S A 114, 4833-4838. 10.1073/pnas.1620955114.

11. Zhou, Y., Romero-Campero, F.J., Gomez-Zambrano, A., Turck, F., and Calonje, M. (2017). H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity. Genome Biol 18, 69. 10.1186/s13059-017-1197-z.

12. Merini, W., Romero-Campero, F.J., Gomez-Zambrano, A., Zhou, Y., Turck, F., and Calonje, M. (2017). The Arabidopsis Polycomb Repressive Complex 1 (PRC1) Components AtBMI1A, B, and C Impact Gene Networks throughout All Stages of Plant Development. Plant Physiol 173, 627-641. 10.1104/pp.16.01259.

13. Zhou, Y., Hartwig, B., James, G.V., Schneeberger, K., and Turck, F. (2016). Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes. Plant Cell 28, 87-101. 10.1105/tpc.15.00787.

14. Förderer, A., Zhou, Y., and Turck, F. (2016). The age of multiplexity: recruitment and interactions of Polycomb complexes in plants. Curr Opin Plant Biol 29, 169-178. 10.1016/j.pbi.2015.11.010.

15. Hu, J.-Y., Zhou, Y., He, F., Dong, X., Liu, L.-Y., Coupland, G., Turck, F., and de Meaux, J. (2014). miR824-Regulated AGAMOUS-LIKE16 Contributes to Flowering Time Repression in Arabidopsis. Plant Cell 26, 2024-2037. 10.1105/tpc.114.124685.

16. Zhou, Y., Zhang, J., Lin, H., Guo, G., and Guo, Y. (2010). MORPHEUS' MOLECULE1 is required to prevent aberrant RNA transcriptional read-through in Arabidopsis. Plant Physiol 154, 1272-1280. 10.1104/pp.110.162131.

17. Zhou, Y., Yang, Z., Guo, G., and Guo, Y. (2010). Microfilament dynamics is required for root growth under alkaline stress in Arabidopsis. J Integr Plant Biol 52, 952-958. 10.1111/j.1744-7909.2010.00981.x.