个人简介

教育经历

1997年8月- 2001年8月，肯塔基大学/University of Kentucky (USA)，Ph.D.（博士学位）

2001年10月- 2005年7月，威斯康星大学麦迪逊分校/University of Wisconsin-Madison (USA)，博士后

2005年8月- 2014年8月，新加坡国立大学/National University of Singapore，助理教授、副教授 (tenured associate professor)

2006年6月- 2014年8月，新加坡淡马锡生命科学研究所/Temasek Life Sciences Laboratory，研究员 (Principal Investigator /PI)，Senior PI

2014年6月- 2020年9月，中国科学院上海生命科学研究院 /中科院分子植物科学卓越创新中心 上海植物逆境生物学研究中心，研究员

2020年10月- 至今，北京大学现代农学院，教授（长聘）

工作经历

科研领域

利用分子、生化、遗传及组学等手段，揭示环境信号包括光周期和冬季低温调控植物开花时间（flowering time）的分子与表观遗传机制。种子植物历经营养生长后转换至生殖生长，其转换时机（即成花转变时间或开花时间）受多种内在因子（如年龄、激素等）与外源环境因素（如日照长度变化、温度等）的调控。这些因素通过多种遗传途径如光周期路径、春化路径、年龄路径等，调控开花时间基因的表达，从而诱导植物开花。研究内容：利用模式开花植物以及主粮作物小麦等，聚焦春化路径及光周期路径，揭示季节转换调控越冬植物在春季开花的分子与表观遗传机制；利用基因编辑等生物技术，改良作物开花时间等农艺性状。

学术发表

1.  Niu D, Gao Z, Cui B, Zhang Y & He Y. (2024) A molecular mechanism for embryonic resetting of winter memory and restoration of winter annual growth habit in wheat. Nature Plants, DOI: 10.1038/s41477-023-01596-6.

2.  Huang F, Luo X, Ou Y, Gao Z, Tang Q, Chu Z, Zhu X & He Y. (2023) Control of histone demethylation by nuclear-localized α-ketoglutarate dehydrogenase. Science, 381: eadf8822.

3.  Zhang Z, Luo X, Yang, Y & He Y. (2023) Cold induction of nuclear FRIGIDA condensation in Arabidopsis. Nature, 7969: E27-E32.

4.  Gao Z, Li Y, Ou Y, Yin M, Chen T, Zeng X, Li R & He Y. (2023) A pair of readers of bivalent chromatin mediate formation of Polycomb-based "memory of cold" in plants. Molecular Cell, 83: 1109-1124.

5.  Xu G, Tao Z & He Y. (2022) Embryonic reactivation of FLOWERING LOCUS C by ABSCISIC ACID-INSENSITIVE 3 establishes the vernalization requirement in each Arabidopsis generation. Plant Cell, 34: 2205-2221.

6.  Li Z, Luo X, Ou Y, Jiao H, Peng L, Fu X, Macho AP, Liu R & He Y. (2021) JASMONATE-ZIM DOMAIN proteins engage Polycomb chromatin modifiers to modulate Jasmonate signaling in Arabidopsis. Molecular Plant, 14: 732-747.

7.  Luo X, Ou Y, Li R & He Y. (2020) Maternal transmission of the epigenetic 'memory of winter cold' in Arabidopsis. Nature Plants, 6: 1211-1218.

8.  Tao Z, Hu H, Luo X, Jia B, Du J* & He Y.* (2019) Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis. Nature Plants, 5: 424-435.

9.  Luo X, Chen T, Zeng X, He D & He Y. (2019) Feedback regulation of FLC by FLOWERING LOCUS T (FT) and FD through a 5' FLC promoter region. Molecular Plant, 12: 285-288.

10.  Li Z, Fu X, Wang Y, Liu R & He Y. (2018) Polycomb-mediated gene silencing by the BAH-EMF1 complex in plants. Nature Genetics, 50: 1254-1261.

11. Li Z, Jiang D & He Y. (2018) FRIGIDA establishes a local chromosomal environment for FLOWERING LOCUS C mRNA production. Nature Plants, 4: 836-846.

12. Z. Li, Y. Ou, J. Li & He Y. (2018) Brassinosteroid signaling recruits Histone 3 lysine-27 demethylation activity to FLOWERING LOCUS C chromatin to inhibit the floral transition in Arabidopsis. Molecular Plant, 11: 1135-1146.

13. Y. He & Li Z. (2018) Epigenetic environmental memories in plants: establishment, maintenance, and reprogramming. Trends in Genetics, 34: 856-866.

14. Z. Tao, L. Shen, X. Gu, Y. Wang, H. Yu & He Y. (2017) Embryonic epigenetic reprogramming by a pioneer transcription factor in plants. Nature, 551: 124-128.

15. Yuan W, Luo X, Li Z, Yang W, Wang Y, Liu R, Du J & He Y. (2016) A cis cold memory element and a trans epigenome reader mediate Polycomb silencing of FLC by vernalization in Arabidopsis. Nature Genetics, 48: 1527-1534.

16. Li Z, Jiang D, Fu X, Luo X, Liu R & He Y. (2016) Integration of histone methylations with RNA processing by the nuclear mRNA Cap Binding Complex. Nature Plants, 2: 16015.